Quick Win
Create a site/web application with very simple and logical structure (navigation and branding in the header on top, then meaningful heading, followed by the main content), dark gray text on a white or very light background. This way you will please all your users, disabled or not. Fill the alt attribute of the images with meaningful content. Try to navigate the site using a (free) screen reader like VoiceOver or ChromeVox, and adjust accordingly.
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